OSD-425 · GLDS-425
The effect of microgravity on the epigenetic modification in C. elegans - JAXA EPIGENETICS spaceflight experiment
Study overview
What the record says
We compared the entire gene expression of wild-type and mutants under µG and artificial 1G conditions. Two independent culture samples were analyzed for each condition. DNA microarray analyses were performed to determine the gene expression profiles of space-flown worms over four generations. N2 wild-type, RB756 hda-4 (ok518), and VC199 sir-2.1 (ok434) mutants were used to analyze epigenome alterations by histone deacetylase.
Structured metadata
Map the experiment
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01
Biological subject
- Organism
- Caenorhabditis elegans
- Material
- Whole Organism
02
Measurement
- Assay
- DNA microarray
- Measures
- transcription profiling
- Platform
- Agilent
03
Experimental factors
- Factor type
- Space Flight Genotype generation Gravity Altered
- Factor name
- Spaceflight, Genotype, Generation, Altered Gravity
04
Mission context
- Flight program
- International Space Station (ISS)
- Space program
- JAXA
People & publication
Follow the work
- Publication
- Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans. Loss of physical contact in space alters the dopamine system in C. elegans.
- Investigators
- Akira Higashibata