OSD-283 · GLDS-283
Dynamic gene expression response to altered gravity in human myelomonocytic U937 cells [parabolic]
Study overview
What the record says
We investigated differentially regulated genes in human myelomonocytic U937 cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to identify potential gravity-regulated genes and adaptation processes. Overall design: Human myelomonocytic U937 cells were exposed to altered gravity during a parabolic flight.
Structured metadata
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01
Biological subject
- Organism
- Homo sapiens
- Material
- Cells
02
Measurement
- Assay
- DNA microarray
- Measures
- transcription profiling
- Platform
- Nimblegen
03
Experimental factors
- Factor name
- Altered Gravity
04
Mission context
- Flight program
- Airbus A300 ZERO-G (reg. no. F-BUAD)
- Space program
- German Aerospace Center (DLR)
People & publication
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- Publication
- Expression of Hypoxia-Inducible Factor 1a (HIF-1a) and Genes of Related Pathways in Altered Gravity Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells Transcriptional Homeostasis of Oxidative Stress-Related Pathways in Altered Gravity
- Investigators
- Cora S Thiel